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innotech
by
zope1
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last modified
2006-01-16 15:21
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The aim of the VIRGIL-INNOTECH platform is to develop key technologies
and methodologies that, following implementation, form the next
generation tools for monitoring viral drug resistance (VIRGIL-CLINVIR),
understanding the molecular basis for drug resistance (VIRGIL-MODELS) and
improving surveillance of drug resistant viruses in the population
(VIRGIL-SURVEIL and -CLINVIR). The activities of this platform can be
divided into two work packages: |
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Viral genomics in which virus replicons, cell lines for phenotypic
analysis of mutant viruses, sensitive nucleic acid amplification assays
and gene chips technology for mutation analysis are being developed. |
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Bio-informatics, -mathematics and -statistics to provide support to the
Virgil network for understanding viral drug resistance at the molecular
level, providing new tools for the analysis of clinical data and modelling
kinetics and spread of resistance. Bio-informatics, in large, has proven
in the last decade to play a crucial role in the rapid development of
biological research and is predicted to become even more important along
with the explosion of biological information to become available. Also in
the field of viral dynamics and resistance mathematical models have shown
their importance in predicting the effect of various therapy regimens
against viral hepatitis and HIV and in understanding patterns of spread of
Influenza resistance. In preparing for future data, novel, integrated and
generic modelling techniques are being developed to enable the integration
and analysis of the data generated by the network and others. |
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The VIRGIL-INNOTECH platform promotes technology transfer of drug
resistance testing tools and innovation aspects to SMEs or bigger
industry companies, and their application to the clinical situation.
Another aim is to coordinate the integrated and smart development of
VIRGIL Internet-based database, linking viral sequence and clinical data
with structural biology and evolution analysis tools that enables the
integration of information emanating from the various parts of the VIRGIL
network. In addition, experts on bioinformatics participating in VIRGIL-INNOTECH
provide expertise in order to make predictions about resistance
mechanisms in cases where no 3D structure is available or to simplify and
accelerate the analysis, especially in cases where large numbers of
mutations must be analysed. |
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Emergence of resistance to oseltamivir among influenza A(H1N1) viruses in Europe